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KMID : 0620920180500070090
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Experimental & Molecular Medicine
2018 Volume.50 No. 7 p.90 ~ p.90
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Spotlight on protein N-terminal acetylation
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Ree Rasmus
Varland Sylvia
Arnesen Thomas
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Abstract
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N-terminal acetylation (Nt-acetylation) is a widespread protein modification among eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino group, the charge, hydrophobicity, and size of the N-terminus is altered in an irreversible manner. This alteration has implications for the lifespan, folding characteristics and binding properties of the acetylated protein. The enzymatic machinery responsible for Nt-acetylation has been largely described, but significant knowledge gaps remain. In this review, we provide an overview of eukaryotic N-terminal acetyltransferases (NATs) and the impact of Nt-acetylation. We also discuss other functions of known NATs and outline methods for studying Nt-acetylation.
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KEYWORD
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Protein folding
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